Functional Blood Chemistry

"There is no general screening test that is more efficient,
effective and affordable than a comprehensive blood chemistry panel. A comprehensive blood chemistry panel will allow the healthcare provider to quickly assess the degree of health or disease in a patient. It is the ultimate tool in biomedical laboratory sciences to evaluate new patients. It allows the healthcare provider to establish a baseline of biomarkers that can be used to track the patient's health immediately and over a period of time."


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The timeless topic of blood chemistry has received a past due makeover from one of the top nutritional clinicians in the country as Dr. Kharrazian has compiled new information gleaned from current medical literature. Dr. Alexander C. Frank has studied Functional Blood Chemistry Analysis with Dr. Kharrazian. It is important to learn to spot patterns that can indicate a myriad of health conditions and gain insight into managing them. Dr. Kharrazian has developed a new reference manual that will doubtlessly become the industry standard and allow Doctors to:

  • See the differences between functional and pathological laboratory evaluations
  • Understand how to identify pathology and when to refer for further testing or more comprehensive management
  • Understand the basic principals of laboratory biochemistry
  • Learn to identify patterns associated with disease and functional imbalances
  • Understand how to differentially diagnose blood chemistry patterns
  • Review the literature in regards to nutritional and herbal compounds that can be used to support abnormal patterns
  • Learn to appropriately manage and follow up patient care with repeat testing

Why Incorporate Blood Chemistry into  Your Healthcare?

A blood chemistry analysis should be considered with all new patients, especially those that have not had a comprehensive evaluation in recent years. Many health problems can be prevented and managed effectively with early detection. The quality of healthcare in the United States has dramatically declined in the past decade. The incorporation of managed care and HMO systems have made dollars spent a priority over insightful health management. Alternative medicine has grown aggressively due to the current allopathic model. Americans are now spending more money out-of-pocket on alternative medicine every year than they have in the past on traditional healthcare. A comprehensive blood chemistry analysis provides the patient and the healthcare providers with peace of mind that their metabolism has been thoroughly screened.

Understanding Blood Chemistry Principals

Although there are some individual test results in blood chemistry that merit evaluation, most blood chemistry markers must be considered along with other test results to make an appropriate diagnosis. Simply stated, with the exception of a few biomarkers, blood chemistry analysis is based on looking for patterns and assessing probabilities based on those results. Occasionally, additional tests will need to be ordered to increase the potential to make a correct diagnosis. Blood chemistry analysis is fundamentally about identifying patterns and relationships between tests to ascertain probabilities. Blood chemistry analysis should always be used in conjunction with a comprehensive medical history that includes past and present illnesses, medication usage, alcohol consumption, herbal and nutritional usage and adequate hydration. It is important for the healthcare provider to understand the identification of patterns and whether any follow-up testing is needed to determine the appropriate diagnosis. Blood chemistry analysis should be analyzed in conjunction with a detailed medical history and physical examination.

Pathological Versus Funtional Ranges

Dr. Frank will spend time explaining to his patients the differences between pathological and functional ranges. A pathological range is used to diagnose disease. A functional range is used to assess risk for disease before disease develops. The main difference between the functional and pathological range is the degree deviation allowed within their normal ranges. For example, the functional range for glucose is 85-100; the pathological range is 65-110. Levels above the pathological range may indicate diabetes. Levels above the functional range, but before they reach the extremes of the pathological range, may indicate insulin resistance and future risk for developing diabetes. Conventional medical training is concerned with the diagnosis of disease and rarely preventative medicine. Healthcare providers that practice preventive medicine are those most inclined to incorporate consulting patients when their levels register outside of the functional range. If biomarkers can be managed before they fall within the pathological range, preventive medicine can be practiced. Traditional healthcare providers usually do not embrace the concept of a functional range. Practitioners who embrace the importance of functional ranges usually are also concerned about diet, nutrition and lifestyle changes.


Datis Kharrazian, D.C., M.S., F.A.A.C.P., D.A.C.B.N., C.N.S., C.S.C.S., C.C.S.P. is a Fellow of the American Academy of Chiropractic Physicians and earned a Master of Science degree in Human Nutrition from the University of Bridgeport. He is a Diplomate of the American Clinical Board of Nutrition, a Diplomate of the Certification Board of Nutrition Specialists and a Certified Clinical Nutritionist by the Clinical Nutrition Certification Board. He is currently completing his dissertation for a Doctorate of Medical Science Degree in Steroid Hormone Biochemistry and Metabolism from the School of Biomedical Sciences at the University of Ulster. He is considered an expert in the bioassay evaluation and the nutritional management of chronically ill patient.